CALL FOR PAPERS Endocrine and Metabolic Dysfunction during Aging and Senescence MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance
نویسندگان
چکیده
Oh Sung Kwon, Ruth E. Tanner, Katherine M. Barrows, Marah Runtsch, J. David Symons, Thunder Jalili, Benjamin T. Bikman, Donald A. McClain, Ryan M. O’Connell, and Micah J. Drummond Departments of Physical Therapy, Pathology and Exercise and Sport Science and Divisions of Nutrition and Diabetes, Metabolism and Endocrinology, University of Utah, Salt Lake City, Utah; and Department of Physiology and Developmental Biology, Brigham Young University, Provo, Utah
منابع مشابه
MyD88 regulates physical inactivity-induced skeletal muscle inflammation, ceramide biosynthesis signaling, and glucose intolerance.
Physical inactivity in older adults is a risk factor for developing glucose intolerance and impaired skeletal muscle function. Elevated inflammation and ceramide biosynthesis have been implicated in metabolic disruption and are linked to Toll-like receptor (TLR)/myeloid differentiation primary response 88 (MyD88) signaling. We hypothesize that a physical inactivity stimulus, capable of inducing...
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